Fatality owing to pulmonary hemorrhage following pamidronate disodium administration in a neonate with osteogenesis imperfecta type 2: a case report
release_dwzvoes445ew5elh5aglmedzmi
by
Rintaro Nagoshi,
Shoichiro Amari,
Yu Abiko,
Yuka Sano Wada,
Akira Ishiguro,
Reiko Horikawa,
Yushi Ito
2024 Volume 33, Issue 2, p76-81
Abstract
We report the case of a patient with osteogenesis imperfecta (OI) who developed pulmonary hemorrhage 4 d after pamidronate disodium (PA) administration, despite a relatively stable respiratory status. Bisphosphonates are introduced to reduce osteoclast activity and are now widely used in patients with OI. Bisphosphonates are typically well-tolerated in children, and the standard of care involves cyclic intravenous administration of PA. However, in practice, there is limited experience with the use of PA for severe OI during the neonatal period, and its safety remains uncertain. This report aimed to describe the respiratory events potentially associated with PA in a neonatal patient with OI type 2, suggesting that serious life-threatening complications of pulmonary hemorrhage may occur after PA administration. Further studies are required to assess the relationship between pulmonary hemorrhage and PA administration, aiming to enhance prophylaxis measures.
In text/plain
format
Archived Files and Locations
application/pdf
426.2 kB
file_b2td3bfgpvcxfcuhdnnzvkqet4
|
www.jstage.jst.go.jp (repository) web.archive.org (webarchive) |
Open Access Publication
Not in DOAJ
In ISSN ROAD
In Keepers Registry
ISSN-L:
0918-5739
access all versions, variants, and formats of this works (eg, pre-prints)
Crossref Metadata (via API)
Worldcat
SHERPA/RoMEO (journal policies)
wikidata.org
CORE.ac.uk
Semantic Scholar
Google Scholar