BibTeX
CSL-JSON
MLA
Harvard
Synthesis and evaluation of antibacterial and antioxidant activity of novel 2-phenyl-quinoline analogs derivatized at position 4 with aromatically substituted 4<i>H</i>-1,2,4-triazoles
release_dsncwyni6rcuhgmtmvo3djsny4
by
Donatella Verbanac,
Ritu Malik,
Mahesh Chand,
Khushbu Kushwaha,
Monika Vashist,
Mario Matijašić,
Višnja Stepanić,
Mihaela Perić,
Hana Čipčić Paljetak,
Luciano Saso,
Subhash C. Jain
Published
by Figshare.
2016
Abstract
A set of novel quinolone–triazole conjugates (<b>12</b>–<b>31</b>) were synthesized in three steps in good yields starting from 2-phenylquinoline-4-carboxylic acid. All the intermediates, as well as the final 1,2,4-triazolyl quinolines were fully characterized by their detailed spectral analysis utilizing different techniques such as IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR, and finally mass spectrometry. All the synthesized compounds were evaluated <i>in vitro</i> for their potential antibacterial activity and their preliminary safety profile was assessed through cytotoxicity assay. Additionally, six selected conjugates were evaluated for their antioxidative properties on the basis of density functional theory calculations, using radical scavenging assay (DPPH) and cellular antioxidant assay. The reported results encourage further investigation of selected compounds and are shading light on their potential pharmacological use.
In text/plain format
Archived Files and Locations
application/pdf
954.1 kB
file_75ptjwd4c5fkzkzxkb3yk7rgde
|
s3-eu-west-1.amazonaws.com (publisher) web.archive.org (webarchive) |
Read Archived PDF
Preserved and Accessible
Type
Stage
Date 2016-06-20
article-journalStage
published
Date 2016-06-20
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
access all versions, variants, and formats of this works (eg, pre-prints)
Cite This
Lookup Links
oaDOI/unpaywall (OA fulltext)
Datacite Metadata (via API)
Worldcat
wikidata.org
CORE.ac.uk
Semantic Scholar
Google Scholar
Datacite Metadata (via API)
Worldcat
wikidata.org
CORE.ac.uk
Semantic Scholar
Google Scholar