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Variceal Bleeding in Patients with Initation of Sofosbuvir and Ribavirin – Case Reports
release_dqjjpspygzhu3azqzy7snasami
by
Sadiq Memon,
Department of Gastroenterology, Asian Institute of Medical Sciences, Hyderabad, Pakistan.,
Madiha Zaki,
Shahzad Ali Jiskani,
Department of Gastroenterology, Indus Medical College Hospital, Tando Muhammad Khan, Pakistan.,
Department of Pathology, Indus Medical College Hospital, Tando Muhammad Khan, Pakistan.
Abstract
Abstract: Sofosbuvir is an oral nucleoside analogue and potent inhibitor of the Hepatitis C virus (HCV) RNA polymerase that is used in combination with other antiviral agents to treat chronic Hepatitis C Nevertheless, and for unknown reasons, successful antiviral therapy of Hepatitis C with Sofosbuvir and other direct acting agents in patients with cirrhosis is occasionally complicated by hepatic decompensation. Here we describe 2 case report of upper gi bleed at initial days of treatment with Sofosbuvir and Ribavirin. Keywords: Variceal bleeding , Sofosdbuvir, Ribavirin, Heptitis C, Nucleoside analogue, Antiviral.
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