Influence of the patient population on the risk of heparin-induced thrombocytopenia release_brigfpjj6rfitp5r2timn2r3im

Abstract

<strong>Abstract:</strong> 744 patients from 3 different clinical settings were evaluated as follows: unfractionated heparin (UFH) during or after cardiac surgery (n=100), UFH after orthopedic surgery (n=100, = 205) and molecular weight heparin (LMWH) after orthopedic surgery (n = 439). In the activation assay, the frequency of HIT-IgG formation varied from a minimum of 3.2% in orthopedic patients receiving LMWH to a maximum of 20% in cardiac patients receiving UFH; per antigen assay, the corresponding frequencies ranged from 7.5% to 50%. However, in patients who developed HIT-IgG and received UFH, the probability of HIT was higher in orthopedic patients than in cardiac patients (according to the activation assay: 52.6% vs. 5%; odds ratio 21.1). [95% CI, 2.2-962.8]; P = .001; nach Antigen-Assay: 34,5 % vs. 2,0 %; Odds Ratio, 25,8 [95 % KI, 3,2-1141]; P &lt; 001). It is concluded that there is an unexpected dissociation between the frequency of HIT-IgG formation and the risk of HIT, which depends on the patient population. <strong>Keywords:</strong> cardiac patients, heparin-induced thrombocytopenia, patient population. <strong>Title:</strong> Influence of the patient population on the risk of heparin-induced thrombocytopenia <strong>Author:</strong> MOHAMMED AYED ALSEFRI, MORAD AYED ALSEFRI, ABDULLAH SALEM ALHARBI <strong>International Journal of Life Sciences Research</strong> <strong>ISSN 2348-313X (Print), ISSN 2348-3148 (online)</strong> <strong>Vol. 10, Issue 4, October 2022 - December 2022</strong> <strong>Page No: 82-86</strong> <strong>Research Publish Journals</strong> <strong>Website: www.researchpublish.com</strong> <strong>Published Date: 22-December-2022</strong> <strong>DOI: https://doi.org/10.5281/zenodo.7472536</strong> <strong>Paper Download Link (Source)</strong> <strong>https://www.researchpublish.com/papers/influence-of-the-patient-population-on-the-risk-of-heparin-induced-thrombocytopenia</strong>
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