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Thyroidectomy for Cancer: The Surgeon and the Parathyroid Glands Sparing release_bbrgllydzre73pjgqrol5beuzy

by Giuliano Perigli, FABIO CIANCHI, FRANCESCO GIUDICI, Edda Russo, Giulia Fiorenza, Luisa Petrone, Clotilde Sparano, Fabio Staderini, Benedetta Badii, Alessio Morandi

Entity Metadata (schema)

abstracts[] {'sha1': '08c85d80597ecabcfd340e55f93d8f7def244bcd', 'content': "Background: The diagnosis of thyroid cancer is continuously increasing and consequently the amount of thyroidectomy. Notwithstanding the actual surgical skill, postoperative hypoparathyroidism still represents its most frequent complication. The aims of the present study are to analyze the rate of postoperative hypoparathyroidism after thyroidectomy, performed for cancer by a single first operator, without any technological aid, and to compare the data to those obtained adopting the most recent technological adjuncts developed to reduce the postoperative hypoparathyroidism. Methods: During the period 1997–2020 at the Endocrine Surgery Unit of the Department of Clinical and Experimental Medicine of the University of Florence, 1648 consecutive extracapsular thyroidectomies for cancer (401 with central compartment node dissection) were performed. The percentage of hypoparathyroidism, temporary or permanent, was recorded both in the first period (Group A) and in the second, most recent period (Group B). Total thyroidectomies were compared either with those with central compartment dissection and lobectomies. Minimally invasive procedures (MIT, MIVAT, some transoral) were also compared with conventional. Fisher's exact and Chi-square tests were used for comparison of categorical variables. p < 0.01 was considered statistically significant. Furthermore, a literature research from PubMed® has been performed, considering the most available tools to better identify parathyroid glands during thyroidectomy, in order to reduce the postoperative hypoparathyroidism. We grouped and analyzed them by technological affinity. Results: On the 1648 thyroidectomies enrolled for the study, the histotype was differentiated in 93.93 % of cases, medullary in 4% and poorly differentiated in the remaining 2.06%. Total extracapsular thyroidectomy and lobectomy were performed respectively in 95.45% and 4.55%. We recorded a total of 318 (19.29%) cases of hypocalcemia, with permanent hypoparathyroidism in 11 (0.66%). In regard to the literature, four categories of tools to facilitate the identification of the parathyroids were identified: (a) vital dye; (b) optical devices; (c) autofluorescence of parathyroids; and (d) autofluorescence enhanced by contrast media. Postoperative hypoparathyroidism had a variable range in the different groups. Conclusions: Our data confirm that the incidence of post-surgical hypoparathyroidism is extremely low in the high volume centers. Its potential reduction adopting technological adjuncts is difficult to estimate, and their cost, together with complexity of application, do not allow immediate routine use. The trend towards increasingly unilateral surgery in thyroid carcinoma, as confirmed by our results in case of lobectomy, is expected to really contribute to a further reduction of postsurgical hypoparathyroidism.", 'mimetype': 'application/xml+jats', 'lang': None}
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release_date 2021-09-23
release_stage published
release_type article-journal
release_year 2021
subtitle
title Thyroidectomy for Cancer: The Surgeon and the Parathyroid Glands Sparing
version
volume 10
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withdrawn_date
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work_id 5eidp227pjc3pmtakeguxyth3y
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crossref.alternative-id ['jcm10194323']
crossref.license [{'URL': 'https://creativecommons.org/licenses/by/4.0/', 'content-version': 'vor', 'delay-in-days': 0, 'start': '2021-09-23T00:00:00Z'}]
crossref.subject ['General Medicine']
crossref.type journal-article
pubmed.pub_types ['Journal Article']