Dynamic Contrast Enhanced Magnetic Resonance Imaging in Evaluation of Various Breast Pathologies with Histopathological Correlation release_a4retyxczze7rc5jndhanpv5lm

Abstract

Introduction: MRI Breast came as a promising modality for evaluation of breast pathologies. Dynamic Contrast-Enhanced (DCE) MRI of the breast has recently emerged as the most sensitive (95-100%) instrument for the detection of breast cancer which makes it an excellent tool in specific clinical situations, such as the screening of patients at high risk for breast cancer, evaluation of the extent of disease in patients with a new diagnosis, axillary carcinoma of unknown primary, assessing neoadjuvant chemotherapy treatment response and detection of local recurrence in patients who have received breast-conservation therapy. Aim: To study the characterization of various breast masses and differentiating breast lesions into benign and malignant based on their contrast enhancement curves and correlating them with histopathological diagnosis. Materials and Methods: An observational Study was performed on 52 patients for duration of two years. For MRI imaging; a Philips Achieva 1.5 Tesla MRI Machine was used. All the patients underwent FNAC and/or HPE following MRI. Patients with lump/ pain in breast, nipple discharge/nipple retraction were included in the study. Results: Most of the patients were females and in 41-50 years age group. Most common type enhancement curve in the malignant tumours was the type 3 curve. Majority of the malignant tumours showed diffusion restriction on DWI. On correlation with histopathology, the sensitivity of MRI was found to be 96.29%, specificity 89.47 %, positive predictive value 92.85% and negative predictive value 94.44% and accuracy 93.47%. Conclusions: Dynamic contrast enhanced MRI is useful in accurate diagnosis of breast lesions, its detection and also in monitoring the breast lesions. MRI has the advantage of being non-invasive, three dimensional and the extension of the lesions are better visualised on MRI.
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