BibTeX
CSL-JSON
MLA
Harvard
Synthesis of -Tosyloxylated gem-Difluoroalkanes via Oxidative Fluorination of Vinyl Sulfonates Featuring A [2,3]-Sulfonyloxy Migration
release_3wwam23wtrfcvaetxq2pozs6cy
by
Wang Honggen,
Fang-Hai Tu,
Zhan Li,
Shuang Yang,
Yin Li,
Dong-Hang Tan,
Qingjiang Li
Released
as a post
by American Chemical Society (ACS).
2021
Abstract
The gem-difluoroalkanes widely exist in pharmaceuticals, agrochemicals and materials. Reported herein is a facile synthesis of tosyloxylated gem-difluoroalkanes via an oxidative fluorination of readily available vinyl sulfonates. An intriguing [2,3]-sulfonyloxy migration is involved as a key step. The OTs group in the product enables a divergent and modular synthesis of a wide variety of functionalized gem-difluoroalkanes via reliable SN2 reactions. Notable features of this protocol include mild reaction conditions, high efficiency and remarkably good functional-group tolerance.
In application/xml+jats format
Archived Files and Locations
application/pdf
960.1 kB
file_3qpz2mqwnbctloyulafkl4figi
|
chemrxiv.org (publisher) web.archive.org (webarchive) |
Read Archived PDF
Preserved and Accessible
Type
Stage
Date 2021-11-12
postStage
unknown
Date 2021-11-12
Work Entity
access all versions, variants, and formats of this works (eg, pre-prints)
access all versions, variants, and formats of this works (eg, pre-prints)
Cite This
Lookup Links
oaDOI/unpaywall (OA fulltext)
Crossref Metadata (via API)
Worldcat
wikidata.org
CORE.ac.uk
Semantic Scholar
Google Scholar
Crossref Metadata (via API)
Worldcat
wikidata.org
CORE.ac.uk
Semantic Scholar
Google Scholar