Effects of Cu, Zn and Their Mixtures on Bioaccumulation and Antioxidant Enzyme Activities in Galleria Mellonella L. (Lepidoptera: Pyralidae) release_372lbg77mvdynfgjjz6ixgwrkq

Abstract

<jats:title>Abstract</jats:title> The effects of Cu, Zn and their mixture on bioaccumulation and antioxidant enzyme activities of midgut and fat body of <jats:italic>Galleria mellonella</jats:italic> larvae were investigated. The application of metals as a mixture showed a synergistic effect and the accumulation levels were increased in both tissues. Zn accumulation increased in midgut and fat body of <jats:italic>G. mellonella</jats:italic> larvae exposed to metal singly. On the other hand, Cu accumulation increased in midgut, while a decrease was observed in fat body exposed to Cu singly. Moreover, it was determined that oxidative stress was occured in midgut and fat body of <jats:italic>G. mellonella</jats:italic> larvae with significant decreases and increases in antioxidant and detoxification enzyme activities when fed singly and in mixture with different concentrations of Cu and Zn. Understanding the reactions of <jats:italic>G. mellonella</jats:italic>, which is a model organism showing immune system responses similar to vertebrates and bioindicator species, to metals by detoxification systems, which is an important parameter in insect physiology, is thought to contribute to future toxicological, genotoxic, physiological and ecotoxicological studies. <jats:italic>G. mellonella</jats:italic> larvae, which were used as a model organism, shows a similar reaction to mammals.
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